The immune system is a magnificent creation, yet frequently, its function and performance are oversimplified. The knowledge about the immune system expanded significantly, but we are still in the infancy in terms of understanding its function. In terms of affecting the function of the immune system in illness, we are simply blind.
The immune system works in the allosteric models. There is simple no homeostasis. The system is continuously challenged and has to be regulated, adjusted, and railed in. All these components create an extremely dynamic system which is responding to gut, skin and oral flora, environmental factors, aging of the system at all the time. The system is frequently challenged by a variety of pathogens and internal damage products. Quite often, the system is able to react without exuberant response or is able to establish a new stasis with the offending agent. Occasionally system is overwhelmed. Sepsis, trauma, or surgery are examples of incredible challenges to the immune system.
The immune system is critical for healing. This healing has to happen in the aftermath of inflammation. There is no redemption without confession as one would say 😉 Immune system is the hormonal regulator. The immune system consists of not only leukocytes but also endothelium and other organs. The immune system comes in many shapes and forms. Each organ has a specific and unique immune system. Communication between a component of the immune system is a critical factor in regulation. Conversely, the break-in co-ordination is the hallmark of immune dysfunction. The complexity of regulation is the primary obstacle in influencing this system in disease. The system is too complicated for current understanding. Perhaps a quantum computer could give us enough power.